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March 3, 1999

Hormone Replacement Therapy for Secondary Prevention of Coronary Heart Disease

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;281(9):794-797. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-9-jbk0303

To the Editor: We commend Dr Hulley and colleagues1 on a well-designed, first-ever randomized trial to evaluate continuous estrogen-progestin hormone replacement therapy (HRT) for the secondary prevention of coronary heart disease (CHD). Surprisingly and disturbingly, the results do not support the beneficial effects of HRT found in observational studies.