Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor
To the Editor: We commend Dr Hulley and
colleagues1 on a well-designed, first-ever randomized trial
to evaluate continuous estrogen-progestin hormone replacement therapy
(HRT) for the secondary prevention of coronary heart disease (CHD).
Surprisingly and disturbingly, the results do not support the
beneficial effects of HRT found in observational studies.
Pan CX, Boal J, . Hormone Replacement Therapy for Secondary Prevention of Coronary Heart Disease. JAMA. 1999;281(9):794–797. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-9-jbk0303
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