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March 3, 1999

Hormone Replacement Therapy for Secondary Prevention of Coronary Heart Disease

Author Affiliations

Copyright 1999 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1999

JAMA. 1999;281(9):794-797. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-9-jbk0303

To the Editor: In HERS,1 there was an increase in the risk of CHD events associated with the use of HRT compared with placebo during the first year of follow-up, but in subsequent years, the risk was lower in women receiving HRT than placebo. In the accompanying Editorial, Dr Petitti2 cites our findings for duration of HRT use3 and suggests that these observational findings on duration of use contradict the clinical trial findings on recency of starting HRT. There are important differences between recency and duration.

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