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March 3, 1999

Hormone Replacement Therapy for Secondary Prevention of Coronary Heart Disease—Reply

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;281(9):794-797. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-9-jbk0303

In Reply: I cannot disagree with Dr Vandenbroucke's statements about widespread overzealous interpretation of the evidence on the possible cardiovascular benefit of HRT. His caution and that of others should be credited. I count myself among the "several researchers" who have consistently presented evidence that the findings of observational studies on the beneficial effects of HRT on cardiovascular disease might be overly optimistic.1,2