Copyright 1999 American Medical Association.
All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1999
In Reply: We are pleased to
see that the human exposure data from the R. J. Reynolds Tobacco
Company Bowman Gray Technical Center also confirm an acute decrement in
lung function following controlled experimental human exposures to
sidestream tobacco smoke. We would encourage Drs Smith and Sears to
publish these findings in full. Previous exposure chamber data have
suggested that adults with asthma may experience even greater declines
in airflow following exposure to environmental tobacco
smoke,1,2 and a more recent study also observed changes in
airway responsiveness in some asthmatic adults exposed under laboratory
conditions.3 Any association between controlled sidestream
tobacco smoke and triglycerides and HDL may have a variety of
correlates, including circulating catecholamines. One would assume,
however, that increased catecholamines, if anything, would produce
bronchodilation, thus increasing airflow. An earlier chamber study that
specifically investigated the question did not find that subject
suggestibility had a meaningful contribution to the physiologic
responses to secondhand smoke.4 The known direct irritants
in secondhand smoke provide substantial biologic plausibility for acute
airway symptoms and obstruction following this exposure.
Eisner M, Blanc P. Respiratory Effects of Secondhand Smoke—Reply. JAMA. 1999;281(12):1083. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-12-jbk0324
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