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May 12, 1999

Evidence Supporting Antileukotriene Agents for Asthma—Reply

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;281(18):1694. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-18-jac90004

In Reply: Dr Go is correct in stating that I used abstracts to support some points. Antileukotriene drugs are, indeed, new asthma treatments, supported by a limited number of published articles. When I used abstracts, I tried to pull together as many supporting abstracts as possible, never using single abstracts to illustrate particular points. Regarding Go's concern with " . . . antileukotriene agents in combination with inhaled beclomethasone or budsesonide are likely to improve lung function and asthma symptoms more than high-dose inhaled corticosteroid therapy alone," that statement was prefaced with "Supporting evidence suggests . . ." In addition to the abstract, I quoted 2 peer reviewed articles to support that point.1,2 Moreover, I agree that new compounds should continue to be carefully peer reviewed, but remind Go that these compounds already have had to pass one of the tougher peer review organizations in the world, the Food and Drug Administration.