Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor
To the Editor: In an astounding
assessment of their own negative outcome, Dr Patchell and
colleagues1 conclude that routine
therapy is justified for patients following surgical resection of a
single brain metastasis. However, in their well-designed, randomized,
multicenter trial, Patchell et al convincingly show that there is no
survival benefit or prolonged maintenance of functional independence in
patients who received postoperative radiation therapy. The authors do
show that the type of death can be altered by a course of radiation
therapy, ie, those treated with radiotherapy were more likely to die of
systemic causes, whereas those in the observation group were more
likely to die of recurrent metastatic disease involving the brain.
Carroll W. Postoperative Radiotherapy for Single Brain Metastases. JAMA. 1999;281(18):1695. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-18-jac90004
Browse and subscribe to JAMA Network podcasts!
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: