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May 12, 1999

Postoperative Radiotherapy for Single Brain Metastases

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;281(18):1695. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-18-jac90004

To the Editor: Dr Patchell and colleagues1 have shown that following surgical excision of a solitary brain metastasis, postoperative radiotherapy delays recurrence in the brain but does not increase median survival or the number of long-term survivors (7/46 in the observation group vs 6/49 in the irradiated group). The authors have also shown a statistically significant correlation between the time from diagnosis of the primary tumor to the development of metastases and the survival time, and a significantly longer survival time in those patients in the observation group who died of systemic disease, compared with the much larger number of patients in the irradiated group who died of systemic disease.