Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor
In Reply: Dr Morris asks about IRB
approval and the number of eligible patients for this trial.
Institutional review board approval was granted without any problem;
previous retrospective studies had both positive and negative
conclusions, and the question addressed by our trial clearly was
unresolved. The number of eligible patients actually was 146. However,
since patients were entered into the study only after they had had
surgery and a clean postoperative magnetic resonance imaging scan, the
number of eligible patients was less than the total number of patients
diagnosed as having single brain metastases.
Patchell RA, Tibbs PA, Regine WF, et al. Postoperative Radiotherapy for Single Brain Metastases—Reply. JAMA. 1999;281(18):1695. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-18-jac90004
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