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June 2, 1999

Glycemic Control and Quality of Life in Patients With Type 2 Diabetes

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;281(21):1985-1986. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-21-jbk0602

To the Editor: The article by Drs Testa and Simonson1 concludes that short-term improvement of glycemic control in patients with type 2 diabetes improves quality of life. However, there are several potential flaws in the study that cloud their conclusions.

Of 1007 patients screened who went through placebo washout, only 594 were subsequently eligible for the study. Excluding this many patients raises a question of selection bias and may not make the results of the study applicable to the general population.2 Additionally, 21% of the patients had not been receiving any therapy prior to randomization. Knowing how this population of untreated patients was distributed in the 2 groups would be helpful.