Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor
To the Editor: The article by Drs
Testa and Simonson1 concludes that short-term improvement
of glycemic control in patients with type 2 diabetes improves quality
of life. However, there are several potential flaws in the study that
cloud their conclusions.
Of 1007 patients screened who went through placebo washout, only 594
were subsequently eligible for the study. Excluding this many patients
raises a question of selection bias and may not make the results of the
study applicable to the
general population.2 Additionally, 21%
of the patients had not been receiving any therapy prior to
randomization. Knowing how this population of untreated patients was
distributed in the 2 groups would be helpful.
Harari A, Iudica-Souza C. Glycemic Control and Quality of Life in Patients With Type 2 Diabetes. JAMA. 1999;281(21):1985–1986. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-21-jbk0602
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