Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor
To the Editor: In her Clinical Crossroads article,
Dr Parry1 neglected 2 points. First, Thys-Jacobs et
al2 reported that economical calcium supplementation (Tums
E-X) reduced core premenstrual syndrome symptoms of negative affect by
48% in 466 patients. Neither the history nor discussion by Parry shed
more light on this possible dietary variable and its interplay with
this complex neurohormonal scenario.3 If the patient is now
"kindling," this supplement could have been appropriate and,
possibly, protective 2 to 3 years ago.
Appleton PE. Clinical Crossroads: A 45-Year-Old Woman With Premenstrual Dysphoric Disorder. JAMA. 1999;281(24):2283. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-24-jbk0623
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