Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor
In Reply: In response
to Dr Appleton, the article by Thys-Jacobs et al1 was an
important study conducted in a large number of women (466 patients)
that suggested the efficacy of calcium supplementation (Tums E-X) in
reducing symptoms of negative affect. Further work is needed to
determine whether this initially promising result can be replicated in
other studies with other patients in whom the diagnosis of premenstrual
dysphoric disorder is confirmed by prospective daily ratings. The
Clinical Crossroads conference given at the Obstetrics and Gynecology
Grand Rounds at Beth Israel Deaconess Medical Center, Boston, Mass, on
which my article in JAMA was based, was held in May 1998,
before the study by Thys-Jacobs et al was published.
Parry BL. Clinical Crossroads: A 45-Year-Old Woman With Premenstrual Dysphoric Disorder—Reply. JAMA. 1999;281(24):2283. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-24-jbk0623
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