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July 21, 1999

Garcinia cambogia for Weight Loss—Reply

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;282(3):233-235. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-3-jac90006

In Reply: The increasing prevalence of obesity combined with the low efficacy of conventional treatments led us to examine the weight-loss effects of G cambogia, a natural source of the citrate-lyase enzyme inhibitor HCA. Our double-blind, randomized controlled trial was designed from the consumer's perspective: we administered either a placebo or widely available G cambogia preparation in suggested amounts along with dietary recommendations typical of that provided in package inserts.1 Our negative observations in the first adequately controlled and reported trial of this widely used herbal agent prompted several letters from readers.