Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor
In Reply: The increasing prevalence of obesity
combined with the low efficacy of conventional treatments led us to examine
the weight-loss effects of G cambogia, a natural
source of the citrate-lyase enzyme inhibitor HCA. Our double-blind, randomized
controlled trial was designed from the consumer's perspective: we administered
either a placebo or widely available G cambogia preparation
in suggested amounts along with dietary recommendations typical of that provided
in package inserts.1 Our negative observations
in the first adequately controlled and reported trial of this widely used
herbal agent prompted several letters from readers.
Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C. Garcinia cambogia for Weight Loss—Reply. JAMA. 1999;282(3):233–235. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-3-jac90006
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