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October 13, 1999

Parkinson Disease in Twins

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;282(14):1328-1329. doi:10.1001/jama.282.14.1328

To the Editor: Dr Tanner and colleagues1 investigated potential genetic contributions to the cause of sporadic Parkinson disease (PD) through the ascertainment of PD in monozygotic (MZ) and dizygotic (DZ) twin pairs and found that concordance for PD was low and was equivalent in MZ and DZ pairs. They concluded that heredity is not a major causal component in most cases of PD.