Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor
In Reply: Dr Parker and colleagues and Dr Simon
raise an intriguing alternative interpretation of our findings. In preliminary
analysis of the family histories for the twin pairs in which at least 1 member
had PD, 7 mothers and 10 fathers (in 16/161 families) are reported also to
have had PD. The failure to show maternal preponderance is not supportive
of a maternally transmitted inherited defect of mitochondrial DNA. However,
other mechanisms, such as de novo mitochondrial mutations, acquired mutations,
or an interaction between an environmental exposure and a functional mitochondrial
abnormality, are not excluded by our findings.
Tanner CM, Goldman SM, Chan P, et al. Parkinson Disease in Twins—Reply. JAMA. 1999;282(14):1328–1329. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-14-jbk1013
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