[Skip to Content]
[Skip to Content Landing]
Citations 0
October 13, 1999

Parkinson Disease in Twins—Reply

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;282(14):1328-1329. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-14-jbk1013

In Reply: Dr Parker and colleagues and Dr Simon raise an intriguing alternative interpretation of our findings. In preliminary analysis of the family histories for the twin pairs in which at least 1 member had PD, 7 mothers and 10 fathers (in 16/161 families) are reported also to have had PD. The failure to show maternal preponderance is not supportive of a maternally transmitted inherited defect of mitochondrial DNA. However, other mechanisms, such as de novo mitochondrial mutations, acquired mutations, or an interaction between an environmental exposure and a functional mitochondrial abnormality, are not excluded by our findings.