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October 13, 1999

Prenatal and Postnatal Methylmercury Exposure and Neurodevelopmental Outcomes

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;282(14):1333-1334. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-14-jbk1013

To the Editor: The Seychelles Child Development Study is a longitudinal study of the effects of prenatal and postnatal exposure to methylmercury from fish consumption on children's development.1 A cohort of 740 mother-infant pairs was enrolled at 6 months of age and examined with age-appropriate developmental tests at 6, 19, 29, and 66 months. Exposure was measured with total mercury concentration in maternal hair during pregnancy and in children's hair at 66 months. Associations between prenatal and postnatal (66-month analyses only) exposure and developmental outcomes were examined with multiple regression analyses, adjusted for covariates. No adverse effects have been found through the 66-month evaluations.1