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December 8, 1999

Moderate- vs High-Dose Methadone for Opioid Dependence

Author Affiliations

Phil B.FontanarosaMD, Interim CoeditorIndividualAuthorMargaret A.WinkerMD, Deputy EditorIndividualAuthorStephenLurieMD PhD, Fishbein FellowIndividualAuthor

JAMA. 1999;282(22):2121-2123. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-22-jbk1208

To the Editor: Dr Strain and colleagues1 addressed the importance of methadone sodium dose in retaining persons dependent on opioids in treatment. In addition to myriad lesser factors, 2 major reasons for patients to discontinue treatment are the level of doses given to patients and the number of times they are required to visit the clinic.2

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