Phil B.FontanarosaMD, Interim CoeditorIndividualAuthorMargaret A.WinkerMD, Deputy EditorIndividualAuthorStephenLurieMD PhD, Fishbein FellowIndividualAuthor
To the Editor: For more than 50 years, there
has been agreement in scientific investigations that "the voluntary consent
of the human subject is absolutely essential."1
The article by Dr Strain and colleagues2
comparing different doses of methadone prescribed for the treatment of narcotic
addiction raises a fundamental question: Can consent to participate in an
experimental protocol be deemed "voluntary" when it is the only means of access
to a medication of known efficacy in reducing morbidity and mortality?
Newman RG. Moderate- vs High-Dose Methadone for Opioid Dependence. JAMA. 1999;282(22):2121–2123. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-22-jbk1208
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