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December 15, 1999

Stress-Induced Immunomodulation

Author Affiliations

Phil B.FontanarosaMD, Interim CoeditorIndividualAuthorMargaret A.WinkerMD, Deputy EditorIndividualAuthorStephenLurieMD PhD, Fishbein FellowIndividualAuthor

JAMA. 1999;282(23):2209-2210. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-23-jbk1215

To the Editor: Dr Glaser and colleagues1 make several interesting and controversial points in their article on stress and infectious disease.

First, they suggest that a relationship between stress and infectious disease is implied by studies showing that stress causes immunosuppression; however, these studies, and those investigating vaccine responses, focus on a surrogate outcome—"immune response"—rather than infectious disease.