Phil B.FontanarosaMD, Interim CoeditorIndividualAuthorMargaret A.WinkerMD, Deputy EditorIndividualAuthorStephenLurieMD PhD, Fishbein FellowIndividualAuthor
In Reply: Compared with the original study
population, men with a history of gallstone disease at the start of the study
tended to fall into the lower categories of coffee consumption (Table 1). This finding is consistent with the hypothesis that coffee
consumption is associated with a decreased risk of gallstone disease. However,
it does not exclude the possibility that the inverse association between coffee
drinking and gallstone disease is due to a reduction of coffee intake because
of symptoms related to gallstones. Therefore, in our original analysis, all
persons with a prior history of gallstone disease were excluded prior to analyses
(regardless of their level of coffee intake).
Leitzmann M, Giovannucci E. History of Hospitals. JAMA. 1999;282(23):2212–2213. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-23-jbk1215
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