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December 15, 1999

History of Hospitals

Author Affiliations

Phil B.FontanarosaMD, Interim CoeditorIndividualAuthorMargaret A.WinkerMD, Deputy EditorIndividualAuthorStephenLurieMD PhD, Fishbein FellowIndividualAuthor

JAMA. 1999;282(23):2212-2213. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-23-jbk1215

In Reply: Compared with the original study population, men with a history of gallstone disease at the start of the study tended to fall into the lower categories of coffee consumption (Table 1). This finding is consistent with the hypothesis that coffee consumption is associated with a decreased risk of gallstone disease. However, it does not exclude the possibility that the inverse association between coffee drinking and gallstone disease is due to a reduction of coffee intake because of symptoms related to gallstones. Therefore, in our original analysis, all persons with a prior history of gallstone disease were excluded prior to analyses (regardless of their level of coffee intake).