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January 26, 2000

Prognostic Value of Pololike Kinase Expression in Melanomas

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorMargaret A.WinkerMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(4):479-480. doi:10.1001/jama.283.4.475

To the Editor: The incidence of cutaneous malignant melanoma is increasing more rapidly than that of any other cancer among the white population.1 Melanomas cause more than 75% of all skin cancer deaths.2 Because the Breslow3 thickness of a primary tumor is related to its metastatic potential, this factor often guides surgical management. However, some thin melanomas can metastasize despite a favorable Breslow thickness.4 Therefore, better prognostic factors are required for definition of malignant potential.