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February 2, 2000

Glycosylated Hemoglobin as a Diagnostic Test for Type 2 Diabetes Mellitus

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(5):605-607. doi:10.1001/jama.283.5.601

To the Editor: The article by Dr Davidson and colleagues1 and the Editorial by Dr Vinicor2 bring attention to the increasing importance of the glycosylated hemoglobin (HbA1C) in the diagnosis and therapy of glucose intolerance and of diabetes mellitus. To simplify the complex approach of Davidson et al, one may say that HbA1C, which is a surrogate test for glycosylation of proteins throughout the body, should be the arbitrator test when a high-sensitivity screening test with a known false-positive rate is used. Vinicor takes a more conservative approach because not all complications of diabetes can be associated with HbA1C results.