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February 9, 2000

Effects of Androstenedione in Young Men

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(6):741-743. doi:10.1001/jama.283.6.741

To the Editor: In the article by Dr King and colleagues,1 supplementation with androstenedione is repeatedly compared with the use of anabolic steroids. Would it not be more valid to compare androstenedione with other naturally occurring compounds that have little androgenic activity, such as dehydroepiandrosterone? Even if androstenedione does produce a small increase in testosterone levels, high normal levels of testosterone have not been shown to cause negative effects in healthy young men.2