Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor
To the Editor: Dr Neugebauer and colleagues1 relate the development of antisocial personality
disorder (ASPD) in early adulthood to the effects of nutritional deprivation
during pregnancy in a Dutch cohort and hypothesize a neurodevelopmental explanation.
The authors have likewise, in the past, suggested higher risks for schizophrenia2 and affective disorders3
with severe prenatal food deprivation in the Netherlands during the German
blockade in World War II. Other studies have suggested similar causation for
development of obesity in adulthood, decreased glucose tolerance in middle
age, altered patterns of birth weight distribution in second-generation offspring
(which Neugebauer et al quote), as well as coronary heart disease and hypertension
in both humans and animal models.4,5
Shiwach RS. Does Prenatal Famine Cause Later Antisocial Behaviors? JAMA. 2000;283(7):887–888. doi:10.1001/jama.283.7.882
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