Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor
To the Editor: Dr Ranieri and colleagues1 demonstrated that among patients affected by acute
respiratory distress syndrome (ARDS), those receiving mechanical ventilation
with conventional ventilation showed significantly higher levels of pulmonary
and systemic mediators compared with patients who received ventilation with
a "lung-protective" strategy. The authors concluded that "mechanical ventilation
can induce a cytokine response that may be attenuated by a strategy to minimize
overdistension and recruitment/derecruitment of the lung." The data suggest
that ventilator-induced lung injury also can result in systemic inflammation
and associated multiple organ failure.
Petrucci N. Ventilator-Induced Lung Injury. JAMA. 2000;283(8):1003–1004. doi:10.1001/jama.283.8.999
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