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February 23, 2000

Ventilator-Induced Lung Injury

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(8):1003-1004. doi:10.1001/jama.283.8.999

To the Editor: Dr Ranieri and colleagues1 demonstrated that among patients affected by acute respiratory distress syndrome (ARDS), those receiving mechanical ventilation with conventional ventilation showed significantly higher levels of pulmonary and systemic mediators compared with patients who received ventilation with a "lung-protective" strategy. The authors concluded that "mechanical ventilation can induce a cytokine response that may be attenuated by a strategy to minimize overdistension and recruitment/derecruitment of the lung." The data suggest that ventilator-induced lung injury also can result in systemic inflammation and associated multiple organ failure.