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March 1, 2000

Residual HIV-1 RNA After Highly Active Antiretroviral Therapy

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(9):1138-1139. doi:10.1001/jama.283.9.1137

To the Editor: Using an ultrasensitive reverse transcriptase polymerase chain reaction (RT-PCR) analytical method, Dr Dornadula and colleagues1 found that human immunodeficiency virus type 1 (HIV-1) RNA (mean level, 17 copies/mL) was detectable in blood plasma of all 22 patients who had previously received suppressive highly active antiretroviral therapy (HAART) and who were found to have fewer than 50 copies/mL of plasma HIV-1 RNA by standard assays.