Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor
To the Editor:Neisseria
gonorrhoeae is a common etiologic agent of pelvic inflammatory disease
(PID).1 The development of PID is likely
determined by both host susceptibility and the virulence of the organism,
and there is clinical evidence that changes in host susceptibility are influenced
by hormonal status. For instance, the incidence of gonococcal PID symptoms
is highest during the early proliferative phase of the menstrual cycle, and
PID is less prevalent among women who use oral contraceptives.1-4
Furthermore, men rarely develop ascending gonococcal infections. Since complement
activity is an important defense against PID,5
we wanted to determine if complement activity is cyclic and thus correlated
with resistance to gonococcal infection.
Nowicki S, Hart-Van Tassell A, Nowicki B. Susceptibility to Gonococcal Infection During the Menstrual Cycle. JAMA. 2000;283(10):1291–1292. doi:10.1001/jama.283.10.1287
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