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March 22/29, 2000

Prostacyclin and Thromboxane and the Development of Preeclampsia—Reply

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(12):1568-1569. doi:10.1001/jama.283.12.1563

In Reply: The first article1 Drs Benigni and Remuzzi refer to is not a study of preeclampsia. It found that low-dose aspirin reduces TxB2 but not PGI2 in women "at risk for pregnancy-induced hypertension."1 The authors specifically note, "The only patient with proteinuria . . . had a glomerular disease before her pregnancy." Thus, Benigni et al do not provide any information on eicosanoid change in preeclamptic women. In fact, only 3 of the 33 women in their "at risk for pregnancy-induced hypertension" group actually developed pregnancy-induced hypertension.