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April 5, 2000

Does Cranberry Juice Have Antibacterial Activity?

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(13):1691. doi:10.1001/jama.283.13.1685

To the Editor: Several articles on the clinical utility of cranberry juice in patients with recurrent urinary tract infections have been published.1-3 Older studies attributed antibacterial activity to organic acids such as hippuric acid.4 However, more recent studies have emphasized the role of components that act by interference with bacterial adherence of Escherichia coli.5 Thus, it seemed important to reassess whether cranberry juice has true broad-spectrum direct antibacterial activity.