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May 3, 2000

Chronic Systemic Inflammation in Overweight and Obese Adults—Reply

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Contributing EditorIndividualAuthor

JAMA. 2000;283(17):2235-2236. doi:10.1001/jama.283.17.2235

In Reply: Dr Vgontzas and colleagues have shown that obese persons with sleep apnea have higher IL-6 concentrations than obese persons without sleep apnea. Other studies making similar comparisons have reported a relatively higher waist circumference and a greater amount of abdominal visceral fat accumulation in obese persons with sleep apnea.1 Abdominal fat distribution was also associated with elevated CRP concentrations in our study. There is still controversy about whether omental adipocytes produce more IL-6 compared with subcutaneous adipocytes.2 Therefore, it would be of interest to determine whether the difference in IL-6 concentrations in obese persons with and without sleep apnea could be explained by differences in fat distribution.