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May 24/31, 2000

AIDS-Related Opportunistic Illness and Potent Antiretroviral Therapy

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Contributing EditorIndividualAuthor

JAMA. 2000;283(20):2653-2654. doi:10.1001/jama.283.20.2653

To the Editor: Dr Ledergerber and colleagues1 presented data on the incidence of opportunistic infections and cancers in human immunodeficiency virus (HIV)–infected persons. They compared the incidence of specific illnesses in the 6-month period before potent antiretroviral therapy with the incidence in periods after initiation of therapy, and concluded that a decreased incidence of some (but not all) illnesses indicated an effect of therapy. However, analytic difficulties complicate interpretation of these trends for individual opportunistic illnesses.