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June 7, 2000

Improving the Conduct and Reporting of Clinical Trials

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Contributing EditorIndividualAuthor

JAMA. 2000;283(21):2787-2790. doi:10.1001/jama.283.21.2787

To the Editor: The experiences reported by Drs Johansen and Gøtzsche1 in conducting their meta-analysis and those of others described in Dr Rennie's editorial,2 whereby pharmaceutical industry sponsors of clinical trials and their authors are less than forthcoming in presenting their results, should surprise no one. As cataloged by Rennie, it has long been the practice of pharmaceutical companies to submit, and for journals to publish, manuscripts that incompletely describe protocols, selectively report results, and slant interpretations.