Stephen J.LurieMD, PhD, Contributing EditorIndividualAuthor
To the Editor: Dr Strawford and colleagues1 report on the effects of oxandrolone on lean body
mass and strength in HIV-infected eugonadal men. Surprisingly, they failed
to reference the initial and, previously, only published clinical trial of
oxandrolone in this setting.2 This multi-institutional
study demonstrated that oxandrolone in doses of 15 mg/d resulted in a sense
of improved well-being and weight gain in HIV-infected men with muscle wasting
and weakness.2 Additional clinical trials
with this agent were suggested.2 Importantly,
in vitro studies3 demonstrated that oxandrolone
does not interfere with the antiretroviral activity of deoxynucleoside analogues.
Fontanarosa PB, Berger JR. Resistance Exercise and Oxandrolone for Men With HIV-Related Weight Loss. JAMA. 2000;284(2):176–177. doi:10.1001/jama.284.2.175
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