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July 12, 2000

Resistance Exercise and Oxandrolone for Men With HIV-Related Weight Loss

Author Affiliations

Stephen J.LurieMD, PhD, Contributing EditorIndividualAuthor

JAMA. 2000;284(2):176-177. doi:10.1001/jama.284.2.175

To the Editor: Dr Strawford and colleagues1 report on the effects of oxandrolone on lean body mass and strength in HIV-infected eugonadal men. Surprisingly, they failed to reference the initial and, previously, only published clinical trial of oxandrolone in this setting.2 This multi-institutional study demonstrated that oxandrolone in doses of 15 mg/d resulted in a sense of improved well-being and weight gain in HIV-infected men with muscle wasting and weakness.2 Additional clinical trials with this agent were suggested.2 Importantly, in vitro studies3 demonstrated that oxandrolone does not interfere with the antiretroviral activity of deoxynucleoside analogues.