Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor
To the Editor: The development of diabetic
retinopathy has been related to hyperglycemia-induced oxidative stress.1 Haptoglobin (HP) is 1 of many known antioxidant
proteins and is encoded by 2 different alleles, whose products differ markedly
in their antioxidant ability.2 Patients
who are homozygous for the 1 allele (HP 1-1) form
dimeric HP molecules, whereas patients who are heterozygous (HP 1-2) or homozygous (HP 2-2) for the 2 allele
form multimers of 2 or more HP molecules. These multimeric HP complexes are
sterically hindered from binding to hemoglobin and also have less access to
the extravascular space. Thus, we hypothesized that HP genotype may predict
susceptibility to diabetic retinopathy.
Nakhoul FM, Marsh S, Hochberg I, Leibu R, Miller BP, Levy AP. Haptoglobin Genotype as a Risk Factor for Diabetic Retinopathy. JAMA. 2000;284(10):1244–1245. doi:10.1001/jama.284.10.1239
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