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October 11, 2000

Quality of Evidence for Treatment of Prostate Cancer—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor

JAMA. 2000;284(14):1785-1786. doi:10.1001/jama.284.14.1783

In Reply: Dr Clarke highlights the importance of systematic reviews of RCTs for providing a reliable summary of the evidence so that patients and physicians can make well-informed medical decisions. High-quality systematic reviews efficiently integrate information and provide data for rational decision making. They establish whether findings are consistent and can be generalized or whether findings vary by subsets. Meta-analyses, where appropriate, can increase power and precision to enhance estimates of treatment effects and exposure risk.1