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November 8, 2000

Race, Parity, and Gestational Diabetes as Risk Factors for Type 2 Diabetes Mellitus—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor

JAMA. 2000;284(18):2318-2319. doi:10.1001/jama.284.18.2317

In Reply: Although the association between high parity and increased risk of type 2 diabetes is not well established, it is certainly a plausible confounder because the effect of pregnancy may mediate this relationship through increased weight gain or other independent pathways. In our study, women were asked to report their number of pregnancies. Additional analyses indicate that this variable was associated both with race and diabetes risk. In general, African American women had a greater number of pregnancies than white women (median numbers of pregnancies were 4 for African American women and 3 for white women). In addition, greater parity was associated with higher diabetes risk (RR, 1.12 per pregnancy; 95% confidence interval [CI], 1.09-1.15).