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November 22/29, 2000

Estimating the Risk of Cancer in Children With AIDS

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor

JAMA. 2000;284(20):2593-2594. doi:10.1001/jama.284.20.2591

To the Editor: Dr Biggar and colleagues1 recently reported elevated risks of cancer in children with AIDS (acquired immunodeficiency syndrome). As contributors of data to this study, we have several concerns about the authors' conclusions.

First, the authors did not measure the effect of perinatal antiretroviral therapy exposure on the relationship between HIV (human immunodeficiency virus) infection and cancer. However, some AIDS registries contain data on perinatal antiretroviral exposure. Evaluation of these data would help confirm that cancer incidence is not related to antiretroviral exposure.