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December 13, 2000

Antiretroviral Therapy and Mortality Among Children With Perinatal HIV Infection

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor

JAMA. 2000;284(22):2871-2872. doi:10.1001/jama.284.22.2869

To the Editor: Dr de Martino and colleagues1 report a lower mortality rate among Italian children infected with HIV (human immunodeficiency virus) who were treated with multidrug regimens. However, we believe that these results may be biased. Because subjects entered the study only after they were diagnosed with HIV, only one third of the sample was followed up prospectively from birth. Asymptomatic children thus could be underrepresented, with a resulting overestimation of the mortality rate.