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December 27, 2000

Safety of Celecoxib vs Other Nonsteroidal Anti-inflammatory Drugs

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor

JAMA. 2000;284(24):3123-3124. doi:10.1001/jama.284.24.3123

To the Editor: Dr Silverstein and colleagues1 suggest that celecoxib appears to be associated with significantly less renal toxicity than therapy with NSAIDs, as do Drs Lichtenstein and Wolfe2 in their Editorial. It is possible, however, that particular NSAIDs have worse outcomes than nonselective NSAIDs and celecoxib. If so, it would be more appropriate to examine reasons for such a finding (eg, concurrent drug regimens that could potentiate renal toxicity of NSAIDs), rather than conclude that celecoxib had a lower rate of renal adverse events than did all nonselective NSAIDs. It is similarly possible that the rates of GI ulcers and ulcer complications could have been influenced by a particular subgroup.