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December 27, 2000

The Spectrum of Pediatric Gastroesophageal Reflux—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor

JAMA. 2000;284(24):3125. doi:10.1001/jama.284.24.3123

In Reply: Dr Furuta and colleagues raise an interesting and important point in asking for a detailed description of the spectrum of phenotypes of the affected subjects in our genetic linkage study of severe pediatric GER. Clearly, the symptoms of patients with primary nonsyndromic pediatric GER, EE, and hiatal hernia can appear to be similar. It is thus desirable when performing genetic linkage studies to ensure that all of the affected individuals have the same phenotype.