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January 10, 2001

Seasonal Variation in Month of Birth and Diagnosis of Early Childhood Acute Lymphoblastic Leukemia

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2001;285(2):168-169. doi:10.1001/jama.285.2.163

To the Editor: Prior studies have indicated a possible role for in utero or early postnatal causes of acute lymphoblastic leukemia in children.1-4 If such causes include seasonally prevalent infectious agents, then temporal patterns of birth month of affected children or the month of onset of leukemia should be expected to vary accordingly. However, studies of this issue have been generally too small to determine trends.We report the seasonal pattern in birth month and month of diagnosis for children with leukemia in the population of Denmark.