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January 17, 2001

Exercise-Induced Oxygen Desaturation as a Late Complication of Meningococcal Septic Shock Syndrome

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2001;285(3):293-294. doi:10.1001/jama.285.3.290

To the Editor: Children who survive meningococcal septic shock syndrome (MSSS) may have long-term lung damage secondary to mechanical ventilation or to the disease itself. We studied the long-term pulmonary sequelae of MSSS and their relationship with several clinical variables during the acute phase of the disease.

We measured lung function parameters (forced expiratory volume in 1 second, forced vital capacity, total lung capacity, residual volume, and diffusing capacity of carbon monoxide) and transcutaneous arterial oxygen saturation (SaO2) during maximal exercise in 18 children an average of 3.4 years (range, 2.2-4.9 years) after receiving mechanical ventilation for MSSS. Median age at the acute phase of disease was 4.7 years (range, 1.6-15.4 years).