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February 14, 2001

Cigarette Smoking and Anxiety Disorders—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;285(6):732-733. doi:10-1001/pubs.JAMA-ISSN-0098-7484-285-6-jlt0214

In Reply: In response to Dr MacCorquodale, our study had sufficient power (β = .80) to detect a moderate association,1 such as a correlation between the rate of cigarette consumption and subsequent anxiety disorders, with an effect size of 0.30.

To address the large CIs, we pooled cases of agoraphobia, generalized anxiety disorder, and panic disorder into a single category. Adolescents who smoked 20 or more cigarettes per day were more than 5 times as likely as other adolescents to develop 1 of these disorders during late adolescence or early adulthood (OR, 7.80; 95% CI, 3.64-16.68). This CI does not yield a precise estimate of the magnitude of the association between adolescent smoking and risk for these anxiety disorders. However, it does indicate that, by early adulthood, there is a 95% probability that adolescents who smoke 20 or more cigarettes per day are at least 3.64 times more likely than other adolescents to develop 1 of these anxiety disorders by early adulthood.