Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
To the Editor: In their Research Letter, Dr Gibbons and colleagues1 reported that the annual US death rate due to Creutzfeldt-Jakob disease (CJD) has been stable since 1985. These estimates, however, are based only on reported cases, and do not include misdiagnosed or preclinical cases. It seems to me that misdiagnosis alone would drastically change these figures. An unknown number of persons with a diagnosis of Alzheimer disease in fact may have CJD, although only a small number of these patients receive the postmortem examination necessary to make this diagnosis. Furthermore, only a few states have made CJD reportable. Human and animal transmissible spongiform encephalopathies should be reportable nationwide and internationally.
Singeltary, Sr TS. Diagnosis and Reporting of Creutzfeldt-Jakob Disease. JAMA. 2001;285(6):733–734. doi:10-1001/pubs.JAMA-ISSN-0098-7484-285-6-jlt0214
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: