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February 14, 2001

Effect of Humor on Allergen-Induced Wheal Reactions

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;285(6):738. doi:10-1001/pubs.JAMA-ISSN-0098-7484-285-6-jlt0214

To the Editor: Norman Cousins1 originally reported that only 10 minutes of laughter alleviated the pain of ankylosing spondyilitis. Subsequently, it has been reported that laughter during a 60-minute humorous video decreased blood cortisol levels and increased natural killer activity in healthy subjects.2 Another study reported that exposure to a 60-minute rakugo (traditional Japanese comic story) decreased blood levels of interleukin 6 and interferon γ and alleviated pain in patients with rheumatoid arthritis.3

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