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February 21, 2001

Treatment of Respiratory Failure With Noninvasive Continuous Positive Airway Pressure—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;285(7):880-881. doi:10.1001/jama.285.7.879

In Reply: We thank Dr Bendjelid and colleagues for their interesting hypothesis. As already stated, the main goal of our study was to enroll patients with acute lung injury. We expected that a small proportion of these patients with a history of cardiac disease would be eventually classified as having acute cardiac decompensation. Our study was thus underpowered to exclude a slight favorable effect of CPAP on acute cardiogenic edema. Prior studies of CPAP have generally not made a clear distinction between diastolic and systolic forms of left cardiac decompensation in cardiogenic pulmonary edema.