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March 21, 2001

Orthostatic Hypotension and Chronic Fatigue Syndrome

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;285(11):1441-1443. doi:10.1001/jama.285.11.1441

To the Editor: Dr Rowe and colleagues1 examined the hypothesis that orthostasis contributes to the symptoms experienced by patients with CFS. They tested this hypothesis by treating patients with CFS with either fludrocortisone or placebo and found that there was no difference in symptoms in either group. Thus, their study corroborates the findings of Peterson et al,2 who also observed no differences in symptom scores in their crossover study comparing fludrocortisone and placebo.