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May 16, 2001

Vitamin E Supplementation in Healthy Persons

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;285(19):2449-2450. doi:10.1001/jama.285.19.2449

To the Editor: In their study of vitamin E on lipid peroxidation, Dr Meagher and colleagues1 did not follow up their subjects long enough to find an effect. Peroxidation activity, or any other activity of fat-soluable vitamins, would most likely take much longer than 8 weeks to occur given their route of absorption and distribution in the body. This study would have been much more valid if it were conducted for 6- to 18-months, as is typical for lipid-lowering agents.