[Skip to Content]
[Skip to Content Landing]
June 6, 2001

Mutation in the SPINK1 Trypsin Inhibitor Gene, Alcohol Use, and Chronic Pancreatitis

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;285(21):2716-2717. doi:10.1001/jama.285.21.2716-a

To the Editor: In industrialized countries, chronic pancreatitis (CP) is caused by long-term alcohol abuse in about 70% of cases, whereas the cause is generally unknown in the other 30% of patients. Furthermore, it is unclear how alcohol use may lead to CP, and wide variation exists among individuals in their susceptibility to alcoholic CP (ACP). Only a minority of frequent drinkers develop ACP.1 However, genetic factors may also affect the pathogenesis of ACP.