[Skip to Content]
[Skip to Content Landing]
July 11, 2001

Cigarette Smoking as a Risk Factor for Pancreatic Cancer in Patients With Hereditary Pancreatitis

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(2):169-170. doi:10.1001/jama.286.2.169

To the Editor: Smoking approximately doubles the risk of pancreatic cancer,1 the fourth most common cause of death from cancer in the United States. In addition, about 5% to 10% of patients have an inherited genetic predisposition to this tumor.2 A large variety of germ-line defects have been detected in families with pancreatic cancer, including the familial pancreatic cancer syndrome, mutations in the BRCA2 gene, the familial atypical multiple mole melanoma syndrome, hereditary nonpolyposis colorectal carcinoma syndrome, the Peutz-Jeghers syndrome, and hereditary pancreatitis.