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August 1, 2001

Laboratory Containment of Wild Poliovirus

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(5):536. doi:10.1001/jama.286.5.536-a

To the Editor: A recent Medical News and Perspectives story reports that the global effort to eradicate poliovirus is 99% complete.1 However, attention recently has been drawn to potential problems with global eradication,2 including reintroduction of wild virus into a country free of circulating wild virus, reversion of the vaccine strain to a more neurotropic form of the virus and subsequent infection with this reverted strain, persistence of the virus in the environment, and failure to maintain adequate immunization levels.